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1

Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery

Pearl, Laurence H., Prodromou, Chrisostomos

Journal:

Annual Review of Biochemistry

Year:

2006

Language:

english

File:

PDF, 1.25 MB

english, 2006

2

Towards meeting the paracelsus challenge: The design, synthesis, and characterization of paracelsin-43, an α-helical protein with over 50% sequence identity to an all-β protein

Jones, David T., Moody, Claire M., Uppenbrink, Julia, Viles, John H., Doyle, Paul M., Harris, C. John, Pearl, Laurence H., Sadler, Peter J., Thornton, Janet M.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 1.06 MB

english, 1996

3

Generation of molecular surfaces for graphic display

Laurence H Pearl, Annemarie Honegger

Journal:

Journal of Molecular Graphics

Year:

1983

Language:

english

File:

PDF, 493 KB

english, 1983

4

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

Martin G Rowlands, Yvette M Newbatt, Chrisostomos Prodromou, Laurence H Pearl, Paul Workman, Wynne Aherne

Journal:

Analytical Biochemistry

Year:

2004

Language:

english

File:

PDF, 417 KB

english, 2004

5

A structural model for the retroviral proteases

Pearl, Laurence H., Taylor, William R.

Journal:

Year:

1987

File:

PDF, 489 KB

1987

6

Glycogen Synthase Kinase-3 Inhibition by Lithium and Beryllium Suggests the Presence of Two Magnesium Binding Sites

W.Jonathan Ryves, Rana Dajani, Laurence Pearl, Adrian J. Harwood

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

7

The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37

S.Mark Roe, Maruf M.U Ali, Philippe Meyer, Cara K Vaughan, Barry Panaretou, Peter W Piper, Chrisostomos Prodromou, Laurence H Pearl

Journal:

Year:

2004

Language:

english

File:

PDF, 862 KB

english, 2004

8

Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases

Polychronopoulos, Panagiotis, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Tarricone, Aldo, Musacchio, Andrea, Roe, S. Mark, Pearl, Laurence, Leost

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 395 KB

english, 2004

9

Structure and Functional Relationships of Hsp90

Prodromou, Chrisostomos, Pearl, Laurence

Journal:

Current Cancer Drug Targets

Year:

2003

Language:

english

File:

PDF, 790 KB

english, 2003

10

Baby Jane and Infant Doe: Treatment of Newborns with Birth Defects: Committee on Individual Rights, Health and Human Services

Laurence D. Pearl

Journal:

The Urban Lawyer

Year:

1984

Language:

english

File:

PDF, 991 KB

english, 1984

11

Let’s talk business: The language recruiters use to attract STEM graduates

Pearl, Alastair O., Orlando, Laurence, Larson, Ian, Rayner, Gerry M.

Journal:

Industry and Higher Education

Year:

2019

Language:

english

File:

PDF, 214 KB

english, 2019

12

Expression and crystallization of the yeast Hsp82 chaperone, and preliminary x‐ray diffraction studies of the amino‐terminal domain

Prodromou, Chrisostomos, Piper, Peter W., Pearl, Laurence H.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 592 KB

english, 1996

13

Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

Dr. James E. H. Day, Dr. Swee Y. Sharp, Dr. Martin G. Rowlands, Dr. Wynne Aherne, Dr. William Lewis, Dr. S. Mark Roe, Dr. Chrisostomos Prodromou, Prof. Dr. Laurence H. Pearl, Prof. Dr. Paul Workman, P

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 545 KB

english, 2010

14

Calculating CPK images on a UNIX workstation

Laurence H. Pearl

Journal:

Journal of Molecular Graphics

Year:

1988

Language:

english

File:

PDF, 435 KB

english, 1988

15

Electron microscopy studies on DNA recognition by DNA-PK

Oscar Llorca, Laurence H Pearl

Journal:

Year:

2004

Language:

english

File:

PDF, 625 KB

english, 2004

16

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2

Stephen Hilton, Sebastien Naud, John J. Caldwell, Kathy Boxall, Samantha Burns, Victoria E. Anderson, Laurent Antoni, Charlotte E. Allen, Laurence H. Pearl, Antony W. Oliver, G. Wynne Aherne, Michelle

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.05 MB

english, 2010

17

Corrigendum to “Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2” [Bioorg. Med. Chem. 18 (2010) 707]

Stephen Hilton, Sebastien Naud, John J. Caldwell, Kathy Boxall, Samantha Burns, Victoria E. Anderson, Laurent Antoni, Charlotte E. Allen, Laurence H. Pearl, Antony W. Oliver, G. Wynne Aherne, Michelle

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 93 KB

english, 2010

18

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James, Martin G. Rowlands, Katherine J. Boxall, Swee Y. Sharp, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, G. Wynne Aherne, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 590 KB

english, 2005

19

Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

Nicolas Proisy, Swee Y. Sharp, Kathy Boxall, Stephen Connelly, S. Mark Roe, Chrisostomos Prodromou, Alexandra M.Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 788 KB

english, 2006

20

Experience and knowledge of young people regarding illicit drug use, 1969–99

J. Denham Wright, Laurence Pearl

Journal:

Year:

2000

Language:

english

File:

PDF, 358 KB

english, 2000

21

Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast

Peter W. Piper, Stefan H. Millson, Mehdi Mollapour, Barry Panaretou, Giuliano Siligardi, Laurence H. Pearl, Chrisostomos Prodromou

Journal:

Year:

2003

Language:

english

File:

PDF, 256 KB

english, 2003

22

A novel expression system of domain I of human beta2 glycoprotein I inEscherichia coli

Yiannis Ioannou, Ian Giles, Anastasia Lambrianides, Chris Richardson, Laurence H Pearl, David S Latchman, David A Isenberg, Anisur Rahman

Journal:

BMC Biotechnology

Year:

2006

Language:

english

File:

PDF, 1023 KB

english, 2006

23

Cloning and expression of the uracil–DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil–DNA glycosylase–UGI complex

Renos Savva, Laurence H. Pearl

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1995

Language:

english

File:

PDF, 298 KB

english, 1995

24

Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV

Sanjeev Kumar, Karen A. Bunting, Jatinderpal Kalsi, John A. Hinks, David S. Latchman, Laurence H. Pearl, David A. Isenberg

Journal:

Year:

2005

Language:

english

File:

PDF, 213 KB

english, 2005

25

Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex

Bin Hu, Chunyan Liao, Stefan H. Millson, Mehdi Mollapour, Chrisostomos Prodromou, Laurence H. Pearl, Peter W. Piper, Barry Panaretou

Journal:

Molecular Microbiology

Year:

2005

Language:

english

File:

PDF, 649 KB

english, 2005

26

Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms

Athanasios Koulis, Don A. Cowan, Laurence H. Pearl, Renos Savva

Journal:

FEMS Microbiology Letters

Year:

1996

Language:

english

File:

PDF, 414 KB

english, 1996

27

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

Cara K. Vaughan, Peter W. Piper, Laurence H. Pearl, Chrisostomos Prodromou

Journal:

Year:

2009

Language:

english

File:

PDF, 872 KB

english, 2009

28

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct

Barrett, Tracey E., Savva, Renos, Barlow, Tom, Brown, Tom, Jiricny, Josef, Pearl, Laurence H.

Journal:

Natural Structural Biology

Year:

1998

Language:

english

File:

PDF, 785 KB

english, 1998

29

Three-dimensional structure, specificity and catalytic mechanism of renin

Sibanda, Bancinyane Lynn, Pearl, Laurence, Blundell, Tom

Journal:

Year:

1983

File:

PDF, 387 KB

1983

30

A second front against AIDS

Blundell, Tom, Pearl, Laurence

Journal:

Year:

1989

File:

PDF, 240 KB

1989

31

Similarity of active-site structures

Pearl, Laurence

Journal:

Year:

1993

File:

PDF, 127 KB

1993

32

Recurrence of a binding motif?

Swindells, Mark B., Orengo, Christine A., Jones, David T., Pearl, Laurence H., Thornton, Janet M.

Journal:

Year:

1993

File:

PDF, 240 KB

1993

33

Shared structural motif in proteins

Swindells, Mark B., Orengo, Christine A., Jones, David T., Pearl, Laurence H., Thornton, Janet M.

Journal:

Year:

1993

File:

PDF, 163 KB

1993

34

The structural basis of specific base-excision repair by uracil–DNA glycosylase

Savva, Renos, McAuley-Hecht, Katherine, Brown, Tom, Pearl, Laurence

Journal:

Year:

1995

File:

PDF, 1.22 MB

1995

35

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes

Zhang, Minghao, Botër, Marta, Li, Kuoyu, Kadota, Yasuhiro, Panaretou, Barry, Prodromou, Chrisostomos, Shirasu, Ken, Pearl, Laurence H

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 1.58 MB

english, 2008

36

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

Pike, Ashley C W, Rellos, Peter, Niesen, Frank H, Turnbull, Andrew, Oliver, Antony W, Parker, Sirlester A, Turk, Benjamin E, Pearl, Laurence H, Knapp, Stefan

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 545 KB

english, 2008

37

Structural basis for recruitment of BRCA2 by PALB2

Oliver, Antony W, Swift, Sally, Lord, Christopher J, Ashworth, Alan, Pearl, Laurence H

Journal:

Year:

2009

Language:

english

File:

PDF, 989 KB

english, 2009

38

Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

Ali, Maruf M. U., Roe, S. Mark, Vaughan, Cara K., Meyer, Phillipe, Panaretou, Barry, Piper, Peter W., Prodromou, Chrisostomos, Pearl, Laurence H.

Journal:

Year:

2006

Language:

english

File:

PDF, 620 KB

english, 2006

39

The problem with pyrimidines

Pearl, Laurence H., Savva, Renos

Journal:

Natural Structural Biology

Year:

1996

File:

PDF, 401 KB

1996

40

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

Prodromou, Chrisostomos, Roe, S. Mark, Piper, Peter W., Pearl, Laurence H.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 955 KB

1997

41

Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase–uracil glycosylase inhibitor protein complex

Savva, Renos, Pearl, Laurence H.

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 735 KB

1995

42

Structural basis for uracil recognition by archaeal family B DNA polymerases

Fogg, Mark J., Pearl, Laurence H., Connolly, Bernard A.

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 3.32 MB

english, 2002

43

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Mark Roe, S, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 391 KB

english, 2004

44

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

Oliver, Antony W, Paul, Angela, Boxall, Katherine J, Barrie, S Elaine, Aherne, G Wynne, Garrett, Michelle D, Mittnacht, Sibylle, Pearl, Laurence H

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 622 KB

english, 2006

45

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase

Yue, Wyatt W, Hassler, Markus, Roe, S Mark, Thompson-Vale, Vivienne, Pearl, Laurence H

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 659 KB

english, 2007

46

Structural model of full-length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA-PKcs

Rivera-Calzada, Angel, Spagnolo, Laura, Pearl, Laurence H, Llorca, Oscar

Journal:

Year:

2006

Language:

english

File:

PDF, 295 KB

english, 2006

47

Letter to the Editor: Backbone1H,13C, and15N resonance assignments for the C-terminal region of Ku86 (Ku86CTR)

Richard Harris, Joseph D. Maman, John A. Hinks, Andrew Sankar, Laurence H. Pearl, Paul C. Driscoll

Journal:

Journal of Biomolecular NMR

Year:

2002

Language:

english

File:

PDF, 59 KB

english, 2002

48

Letter to the Editor: Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

Reza M. Salek, Mark A. Williams, Chrisostomos Prodromou, Laurence H. Pearl, John E. Ladbury

Journal:

Journal of Biomolecular NMR

Year:

2002

Language:

english

File:

PDF, 69 KB

english, 2002

49

Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications

Stefanie Reich, Loretto H. Puckey, Caroline L. Cheetham, Richard Harris, Ammar A.E. Ali, Uma Bhattacharyya, Kate Maclagan, Keith A. Powell, Chrisostomos Prodromou, Laurence H. Pearl, Paul C. Driscoll,

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 556 KB

english, 2006

50

Influence of academic stress and season on 24-hour mean concentrations of ACTH, cortisol, and β-endorphin

William B. Malarkey, Dennis K. Pearl, Laurence M. Demers, Janice K. Kiecolt-Glaser, Ronald Glaser

Journal:

Psychoneuroendocrinology

Year:

1995

Language:

english

File:

PDF, 716 KB

english, 1995